PEG antibodies in the general population
https://pubmed.ncbi.nlm.nih.gov/27804292/
PEG 3350 hypersensitivity may be more common than was thought https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706272/
Polyethylene glycol as a cause of anaphylaxis
https://www.researchgate.net/publication/311625037_Polyethylene_glycol_as_a_cause_of_anaphylaxis
Anaphylactic Shock Caused by Ingestion of Polyethylene Glycol
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316229/#:~:text=However%2C%20fatal%20adverse%20events%20rarely,reported%20mainly%20in%20Western%20countries.
PEG-induced Anaphylactic Reaction During Bowel Preparation
ttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508945/#:~:text=Few%20allergic%20reactions%20from%20this,to%20provoke%20an%20anaphylactic%20reaction.
Preexisting anti-PEG antibodies are associated with severe immediate allergic reactions
https://www.jacionline.org/article/S0091-6749(16)30605-4/abstract
Anaphylactic Shock Due to Allergy to Magrocol 4000
ttps://www.researchgate.net/publication/317672500_Anaphylactic_Shock_Due_to_Allergy_to_Macrogol_4000_Contained_in_SonoVue_R
Antibodies created with repeated use of PEG
" The functionalization of nanocarriers with PEG enables the efficient delivery of hydrophobic drugs, improves circulation time, increases mucus-penetration, and enhances the stability of biologically fragile therapeutics."
" Over the last couple of decades, free PEGs have been utilized for numerous applications such as osmotic laxatives, topical medications, cosmetics, and in various other household and consumer products [26,38,52]. Consequently, many patients have previously been exposed to PEG, resulting in the detection of anti-PEG antibodies in human blood prior to the administration of PEGylated drugs/NPs (Figure 2b,c) [44,53,54]. "
"However, PEG immunogenicity is a growing issue that limits the efficacy of both commercially available medications and future therapeutics that are currently in development and, critically, may lead to adverse impacts on patient health."
" We envision that, in the near future, PEG will remain the most widely used polymer in drug delivery and bioconjugation, while the search for PEG alternatives will become a hot topic and an important race."
res.mdpi.com/d_attachment/polymers/polymers-12-00298/article_deploy/polymers-12-00298.pdf
https://pubmed.ncbi.nlm.nih.gov/27804292/
PEG 3350 hypersensitivity may be more common than was thought https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706272/
Polyethylene glycol as a cause of anaphylaxis
https://www.researchgate.net/publication/311625037_Polyethylene_glycol_as_a_cause_of_anaphylaxis
Anaphylactic Shock Caused by Ingestion of Polyethylene Glycol
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316229/#:~:text=However%2C%20fatal%20adverse%20events%20rarely,reported%20mainly%20in%20Western%20countries.
PEG-induced Anaphylactic Reaction During Bowel Preparation
ttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508945/#:~:text=Few%20allergic%20reactions%20from%20this,to%20provoke%20an%20anaphylactic%20reaction.
Preexisting anti-PEG antibodies are associated with severe immediate allergic reactions
https://www.jacionline.org/article/S0091-6749(16)30605-4/abstract
Anaphylactic Shock Due to Allergy to Magrocol 4000
ttps://www.researchgate.net/publication/317672500_Anaphylactic_Shock_Due_to_Allergy_to_Macrogol_4000_Contained_in_SonoVue_R
Antibodies created with repeated use of PEG
" The functionalization of nanocarriers with PEG enables the efficient delivery of hydrophobic drugs, improves circulation time, increases mucus-penetration, and enhances the stability of biologically fragile therapeutics."
" Over the last couple of decades, free PEGs have been utilized for numerous applications such as osmotic laxatives, topical medications, cosmetics, and in various other household and consumer products [26,38,52]. Consequently, many patients have previously been exposed to PEG, resulting in the detection of anti-PEG antibodies in human blood prior to the administration of PEGylated drugs/NPs (Figure 2b,c) [44,53,54]. "
"However, PEG immunogenicity is a growing issue that limits the efficacy of both commercially available medications and future therapeutics that are currently in development and, critically, may lead to adverse impacts on patient health."
" We envision that, in the near future, PEG will remain the most widely used polymer in drug delivery and bioconjugation, while the search for PEG alternatives will become a hot topic and an important race."
res.mdpi.com/d_attachment/polymers/polymers-12-00298/article_deploy/polymers-12-00298.pdf